Job Postings

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Employment Opportunities

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Posted July 8, 2010

Company Name: Roche
Location: Switzerland—Basle-Town, Basle

Job Title: Laboratory Head Cardiovascular Safety
Req. ID: 00021781

Who We Are

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity, and on seeing each other’s differences as an advantage. To innovate healthcare, Roche has ambitious plans to keep learning and growing—and is seeking people who have the same goals for themselves.

The headquarters in Basel is one of Roche’s largest sites, over 8,000 people from approximately 80 countries work at Roche Basel. Favored by its geographic location in the heart of Europe, the Basel area is one of the most dynamic economic regions in Switzerland—a great place to live and work.

The Position

The global safety pharmacology group supports safety evaluation of novel drugs throughout preclinical development. Its tasks are to identify and characterize the potential undesirable pharmacodynamic effects of drugs in various study types and publish the data in high quality regulatory submissions.

As a laboratory head in cardiovascular safety at our Basel site you will be responsible for the following areas:

• Lead the in-vivo cardiovascular safety pharmacology laboratory (telemetry), maintain state of the art technology
• Design, oversee and conduct of GLP and non GLP telemetry studies, monitor cardiovascular studies conducted at contract research organizations (CROs)
• Follow up on newest scientific and regulatory developments in the field of safety pharmacology
• Advise project teams on cardiovascular issues and their resolution, provide expertise and guidance for nonclinical safety assessment.
• Prepare documents to support international clinical trials and product registration.
• Provide supervision and mentorship to technical staff
• Maintain a collaborative relationship with safety pharmacology colleagues from our research site in Nutley, NJ
• Adhering to safety standards and policies regulating the care and use of laboratory animals
• Position closing date: mid of August.

Who You Are

You’re someone who wants to influence your own development. You’re looking for a company where you have the opportunity to pursue your interests across functions and geographies, and where a job title is not considered the final definition of who you are, but the starting point.

You enjoy working in a multidisciplinary, international, and highly interactive environment.

To be successful in this role you bring the following qualifications:

• A doctoral degree (Ph.D.) in veterinary science, physiology, medicine, biological science or related areas
• Preferably 3–5 years experience in in-vivo cardiovascular (safety) pharmacology or toxicology
• Knowledge in the evaluation of ECGs
• Excellent written and verbal communication skills in German and English
• Proficiency in Microsoft Office applications
• Experience in working in a GLP regulated environment and familiarity in establishing ex-vivo cardiac models (Langendorff) would be additional assets

To apply for this position please visit the Roche Web site.

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Posted July 2, 2010

Company Name:Novartis
Location: East Hanover, New Jersey

Job Title: Scientist I
Req. ID: 69718BR

A health care company with global reach. A product pipeline filled to the brim. A team committed to scientific advancement.

Think what’s possible.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented, performance driven people. All of which makes us the most rewarding employer in our field.

Job Description

• Work with statistician to develop/validate appropriate statistical methods for evaluating telemetry data.
• Contribute to ECG review and arrhythmias screening in pre-test and in study.
• Displays a high level of competence in the use of all laboratory instrumentation (hardware and software) that are routinely employed and has the ability to trouble-shoot equipment problems.
• Communicates study results and interpretations in an accurate and timely manner.
• Responsible for training less experienced personnel in all phases of study conduct.
• Apply scientific knowledge to develop new methodologies/techniques and optimize existing models/methods.
• Provide guidance in the area of cardiovascular safety pharmacology and maintain state-of-the-art laboratory for conducting telemetry study in animals.
• Assists in response to QAU audit and participates in all applicable corrective action.
• May be required to respond to questions posed by U.S. FDA/U.S. EPA/USDA auditors during inspections.
  
  

Requirements

• BS or MSc degree and major in physiology, pharmacology, biomedical engineering or related field.
• Prefer 5–10 years experience in cardiovascular physiology and/or pharmacology research.
• Prefer minimum of 2 years experiences in cardiovascular safety pharmacology research.
• Experience in setting up, conducting and reporting of telemetry studies in dog and monkey.
• Familiar with EMKA jacket system or other external jacket telemetry system and have experience in EMKA ECGAuto computer software (or similar computer software) to analyze cardiovascular telemetry data.
• Experience in using Excel and SAS macro to analyze and report cardiovascular parameters in telemetry.
• Experience in ECG analyses including ECG interval measurements and waveform abnormalities screening in dog and monkey.

Novartis is an equal opportunity employer m/f/d/v.

To Apply for this position, please visit the Novartis Web site.

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Posted June 29, 2010

Company Name: Vertex Pharmaceuticals
Location: Cambridge, Massachusetts

Job Title: Research Scientist II
Req. ID: 1001957

We are seeking an experienced scientist to help establish the Cardiovascular Science Core for Drug Discovery Research.

• The Research Scientist II will be a key member of the General/Safety Pharmacology group in the Research Department and support Vertex drug discovery projects worldwide. The position involves both working individually and as a member of a team. He/she will collaborate with other members of the General/Safety Pharmacology group as well as members of Ion Channels Biology, Drug Innovation Pharmacokinetics.
• Biomarker Research and Transformational Pharmacology, and Toxicology groups and provide his/her cardiovascular expertise to help evolve the strategy for preclinical safety assessment of lead optimization compounds.
• He/she will be responsible for identification, design, conduct, interpretation, and reporting of high quality cardiovascular pharmacology studies with excellent translational potential for drug development.
• As part of these responsibilities, he/she will regularly represent General/Safety Pharmacology to project teams and present study summaries with firm scientific conclusions, generate new hypotheses, and guide other team members in integrating physiological information to enhance understanding of compound safety. He/she will also be expected to demonstrate sound judgment when contributing to recommendations for advancing safe compounds. If qualified, he/she may outsource studies, or supervise other personnel in the future.
  
  

Qualifications:

• The ideal candidate for this position will be highly motivated and minimally have an MS degree with at least 10 years, or a PhD with at least 8 years of hands-on experience in using relevant general/safety pharmacology assays, such as cardiovascular telemetry or Langendorff heart perfusion.
• Extensive understanding of cardiovascular pharmacology and physiology is required.
• Demonstrated independent thinking, trouble-shooting skills, and ability to analyze, interpret, and translate physiological function data is a must. Industry non-clinical research experience and experience with assessing drug-induced QT prolongation is preferred.
• Extensive knowledge of Data Sciences International/Ponemah (P3P and DataQuest), EMKA Technologies, or similar software packages is necessary.
• Ability to write basic programs using SAS software for data analysis and statistics is a plus.
• The candidate must be able to work independently and in a matrix and function team environment.
• Strong written and oral communication skills are required, including excellent report writing and presentation skills.
• Study outsourcing and/or supervisory experiences are a plus.

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer, and pain.

Vertex Pharmaceuticals Inc., is an Equal Opportunity Employer.

To Apply for this position, please visit the Vertex Web site.

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Posted June 4, 2010

Company Name: Bristol-Myers Squibb, Research and Development
Location: Princeton, New Jersey

Job Title: Senior Research Investigator
Req. ID: 1001957

Description:
An opportunity exists in the Discovery Toxicology and Cardiovascular Safety Pharmacology group responsible for exploratory toxicology studies, and exploratory and IND-enabling large animal cardiovascular telemetry studies.

Essential duties and responsibilities include:

• Design, oversee the conduct, interpret the results and report the findings of nonclinical toxicology and cardiovascular safety pharmacology studies (in house, contract or collaborative).
• Preparation of documents to support international clinical trials and product registration.
• Represent Discovery Toxicology to Discovery/Development teams and provide expertise and guidance for nonclinical safety assessment and CV safety pharmacology planning and issues resolution. Contribute to an integrated understanding of potential liabilities as part of a broad risk assessment perspective.
• Develop approaches to address toxicity issues that arise in Discovery/Development programs.
• Provide supervision and mentorship to technical staff.
• Adhere to safety standards and policies regulating the care and use of laboratory animals.
  
  

Qualifications:

• MS or Ph.D. or equivalent experience in Toxicology or Pharmacology
• In-depth knowledge of toxicology, cardiovascular safety pharmacology, drug metabolism and pharmacokinetics, including molecular and biochemical aspects.
• Experience in nonclinical discovery/development toxicology, including broad-based expertise in animal experimentation (rodent and nonrodent).
• Capability in the role of Study Director (study design, conduct and reporting) and a working knowledge of appropriate international regulatory guidelines governing pharmaceutical development, including GLP, ICH S7a and b, and laboratory animal care and use regulations is required; interaction with regulatory authorities is desirable.
• Experience in cardiovascular physiology and safety pharmacology is desirable.
• Strong team, communication and some supervisory skills are essential.
  
  

How to Apply:
Via the Internet, go to the Bristol-Myers Squibb Web site and search under Job Number 1001957.

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Posted June 4, 2010

Company Name: Bristol-Myers Squibb, Research and Development
Location: United States

Job Title: Associate Research Scientist
Req ID: 1001952

Description:
An opportunity exists in the Cardiovascular Safety Pharmacology group responsible for exploratory and IND-enabling large animal telemetry studies to support candidate selection and regulatory filings.

Essential duties and responsibilities include:

• Collect all study data types in support of cardiovascular large animal telemetry system studies. Coordinate pre-study activities. Lead study assigned technical staff during study conduct to ensure GLP, SOP, and study protocol adherence, and ensure accurate data collection.
• Conduct data reviews within the department to ensure accuracy, completeness, and regulatory compliance.
• Assume select operational responsibilities (e.g. scheduling, animal procurement, equipment procurement and maintenance, SOP generation and maintenance, and/or general systems support, etc.) for cardiovascular safety pharmacology.
• Assist with study protocol and report generation.
• Assist in the conduct of studies to support projects performed in other cardiovascular safety pharmacology laboratories.
• Support Discovery Toxicology, as appropriate.
• Participate in activities outside of the department as appropriate such as safety committee and ACUC memberships.
  
  

Qualifications:

• BS degree or equivalent experience in Toxicology or Pharmacology
• Familiarity with automated systems for the collection of cardiovascular data from instrumented animals
• Experience with routine laboratory procedures associated with safety testing of rodent and non-rodent species
• Experience as a leader responsible for the planning and conduct of assigned studies, and
• Experience performing studies in compliance with Good Laboratory Practice standards (21 CFR Part 58 or equivalent) and appropriate laboratory animal care and use regulations.
• Strong team and communication skills are essential.
• Experience coordinating general departmental operations, and experience in cardiovascular physiology and safety pharmacology are desirable.
  
  

How to Apply:
Via the internet, go to the Bristol-Myers Squibb Web site and search under Job Number 1001952.

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Posted May 4, 2010

Company: Pfizer Inc.
Location: Sandwich, GB

Job Title: Senior Cardiovascular Safety Pharmacologist, Sandwich UK
Salary: Salary commensurate with experience

Description:
This is your opportunity to join Pfizer R&D’s Global Safety Pharmacology department and contribute to our success in delivering new medicines from bench to bedside. In this role you will:

• Partner globally with R&D scientists and clinicians to shape new and important drug developments from initial discovery through to product launch
• Join a recognised industry leader in Safety Pharmacology
• Thrive in an environment that actively promotes scientific publishing
• Work to high standards including Good Laboratory Practice (GLP) generating high quality data and solving complex safety problems
• Interface with key external regulatory and scientific stakeholders
  
  

Qualifications:
We are looking for a highly experienced in vivo scientist to join the Cardiovascular (CV) Discipline to meet the demand for the development of new, and the application of established, in vivo models of CV function. The position involves working both individually and as part of a team to conduct in vivo experiments to assess the cardiovascular (CV) safety of putative new medicines in support of both drug discovery as well as regulatory requirements. The role offers the chance to work across the Pfizer portfolio and is one of high responsibility and impact in drug discovery and development.

The role will involve interacting with both research and development teams as well as exploiting new opportunities such as incorporation of safety pharmacology endpoints (e.g. ECG measurements) in toxicology studies. As part of a global team you will have a network of partners at other sites that you will work with to share learning and develop our expertise and ability to manage this key safety issue. It is expected that you will contribute to the development of the CV discipline strategy, potentially running global initiatives in support of this.

The successful applicant requires an extensive understanding of cardiovascular pharmacology and physiology with hands-on experience of in vivo models and experience of performing investigative studies to evaluate the potential of new drug candidates to cause undesired effects on the cardiovascular system. This position requires independent scientific thinking, trouble-shooting skills, and judgment as actions are expected to impact departmental, site and global goals.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the U.S. for Pfizer. Pfizer retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified U.S. workers. Individuals requiring sponsorship must disclose this fact.

How to Apply:
Pfizer Jobs Web site

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Posted April 30, 2010

Company: Covance
Location: Madison, WI, USA

Job Title:Senior Cardiac Safety Expert
Req. ID: 21439

Description:
Covance is a leading supplier of drug development services to the biotechnology and pharmaceutical industries. We partner with innovative companies, offering valuable services in all phases of the drug development process as well as analytical and commercial impact services. As an integral part of these partnerships, our employees make a difference in the lives of millions.

The Senior Cardiac Safety Expert serves as the scientific specialist in nonclinical cardiac safety for toxicology and safety pharmacology across all North America facilities. This position operates as a Principal Investigator and has overall responsibility for the interpretation, analysis, documentation, and reporting of electrocardiography results.

This role assists or may plan, design, and/or lead a team to conduct complex studies to generate high quality scientific results on behalf of Covance clients and play a key role in developing new strategies, techniques, and instrumentation for new ventures and critical issues in the area of specialty.

Requirements:

• Ph.D. in cardiovascular physiology, pharmacology or related subject, relevant experience may be substituted for education.
• Clinical veterinary medical training (DVM or equivalent degree) is strongly preferred
• 5+ years of related experience
• Recognized expertise in nonclinical electrocardiography, with specific emphasis on the cardiovascular safety assessment of human drugs (evaluation of drug effects on ventricular repolarization, cardiac conduction and arrhythmias)
• History of maintaining an awareness of regulatory developments (FDA and international) in the field of nonclinical cardiac safety assessment
• Highly skilled in conducting research, data interpretation, writing reports, performing scientific presentations, and preparing scientific publications
  

At Covance, we help make the miracles of medicine a reality. We offer opportunities to work on diverse, challenging projects with bright, interesting colleagues while building a flexible and rewarding career. To learn more about Covance and to apply, please visit our Web site and search for Req. ID 21439.

Diversity with Covance is alive and universal. EOE

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Posted April 13, 2010

Company: Covance
Location: USA—Madison, WI or UK—Harrogate

Job Title: Global Chief Scientific Officer—Safety Pharmacology
Req. ID: 21393

At Covance, you can make a difference by helping to deliver life-saving and life-enhancing medicines to people around the world. Our commitment to this mission has resulted in Covance’s impressive history of company stability and growth. We’ve achieved these results by fostering a work environment that encourages, develops and leverages our team's capabilities. We have a unique opening for a Global Chief Scientific Officer—Safety Pharmacology.

This person will be expected to:

• Drive the successful development and execution of the Strategic Plan for Global Safety Pharmacology that delivers targeted growth rates and scientific objectives.
• Assure global annual orders, financial (revenues and operating margin), quality, scientific, and client service targets are achieved in the Global Safety Pharmacology business segment.
• Identify opportunities for strategic Global Safety Pharmacology relationships with Covance clients, and then work with Business Development to manage these relationships.
• Demonstrate and articulate the vision for ensuring global scientific best practices are identified and leveraged as appropriate in Safety Pharmacology.
• Improve the scientific profile of Covance through attendance and presentation at Scientific Symposia and Meetings.
  
  

Qualifications include:

• Ph.D. in Toxicology or related field plus 15 years related experience.
• Strong knowledge of Safety Pharmacology, as evidenced by name recognition in the industry, presentations given, and papers published, etc.
• Strong leadership skills based on Covance Leadership Competencies.
• Skilled in performing presentations and leading meetings.
• Skilled in time management, planning, budgeting and negotiating.
• Demonstrated ability to identify, diagnose and correct processes.
  
  

At Covance, we help make the miracles of medicine a reality. We offer opportunities to work on diverse, challenging projects with bright, interesting colleagues while building a flexible and rewarding career. To apply, please visit our Web site and search for Req. ID 21393.

Diversity with Covance is alive and universal. EOE

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Posted January 15, 2010

Company Name: Novartis Institutes for BioMedical Research, Inc.
Location: Cambridge, MA

Job Title: Postdoctoral Fellow, NIBR
Req. ID: 60538BR

Description:
This is an exciting opportunity to perform academic-oriented research in an industrial setting at the Lead Finding Platform, Novartis Institutes for BioMedical Research Inc, Cambridge, MA.

The NIBR postdoctoral fellow will be responsible for a project to evaluate the utility of human stem cell-derived cardiomyocytes for preclinical safety profiling and drug discovery. The fellow will study the ion channel interplay and action potential waveforms under the influence of various agents and model conditions. This fellow will develop in vitro assays in human stem cell-derived cardiomyocytes using electrophysiology techniques and be involved in data interpretation to predict in vivo and ultimately clinical performance based on in vitro results.

The fellow will have opportunities to interact with experts from multidisciplinary teams and have access to cross-departmental state-of-the-art resources. The work carried out by this individual is expected to lead to high quality publications in peer reviewed journals. Key features of this position include rigorous scientific training, mentorship, and high visibility within research at Novartis and opportunities to interact with senior scientific leadership individually and at annual forums.

About NIBR:
“There is no greater privilege than to work towards bettering human health, and no more exciting arena in which to do so than through discovery of new medicines.”—Mark C. Fishman, President, Novartis Institutes for BioMedical Research

Requirements:
Ph.D. degree with less than 3 years of post-Ph.D. research experience in pharmacology, physiology, or other related discipline is required. Hands-on in vitro electrophysiology experience is a must. Previous experience in cardiomyocyte electrophysiology and/or stem cell-derived cell systems would be desirable but not essential. The candidate must be able to work independently and have strong oral and written communication skills.

To apply please visit the Novartis Web site and search by Job code, 60538BR

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Posted January 12, 2010

Company Name: Covance
Location: Greenfield, IN

Job Title: Research Associate I, Telemetry
Req. ID: 18779

Description:
Covance, one of the world’s largest and most comprehensive drug development services companies is seeking a Research Associate I, Telemetry to work in our Greenfield, IN location. In this position you will be responsible for maintaining an inventory of the instrumented animal colonies for assessing cardiovascular and electroencephalographic activity. Scheduling of periodic signal assessment and cross-function activities for client studies are important responsibilities for this position. Additionally, you will be setting up and maintaining computer systems to acquire experimental data. This position provides an excellent opportunity for job and responsibility growth.

Qualifications:

• Bachelor’s Degree in Science/Arts (BS/ BA) in biological field
• 3+ years of related laboratory experience
• Basic understanding of central nervous system and cardiovascular physiology and pharmacology
• Proficiency with Microsoft Office and computer based software for graphing and data reduction
• Effective communication (verbal and written) including presentation and interpersonal skills
• Problem-solving skills
  
  

At Covance, we are committed to offering a competitive benefits package while providing our employees a flexible, rewarding career. To find out detailed information about this opportunity, please visit our Web site and search for Req. ID 18779.

Diversity within Covance is alive and universal. EOE