Safety Pharmacology Society

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Employment Opportunities

Current Postings

Covance, Greenfield, Indiana
Research Associate—Neuroscience)

Pfizer, Groton, Connecticut
Ion Channel Pharmacology Scientist (R2-Sr. Associate Scientist / R3-Scientist)

Battelle, Columbus, OH
Study Director

Pfizer, United States-Connecticut-Groton
Senior Lab Scientist (CV Safety Pharmacology) (Sr. Scientist / Principal Scientist)

Vertex Pharmaceuticals, Cambridge, MA
Associate Director, Safety Pharmacology, Toxicology

Novartis, Basel (Switzerland) or East Hanover (New Jersey USA)
Novartis will support international family relocation
Global Head, Safety Pharmacology (Director/Executive Director)

The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA
Postdoctoral Fellow

Covance, Madison, WI
Safety Pharm Study Director

Vertex Pharmaceuticals, Cambridge, MA
Safety Medical Director

Posted January 31, 2012

Company Name: Covance
Location: Greenfield, Indiana
Job Title: Research Associate—Neuroscience

Covance offers extraordinary career opportunities to our employees. Here you will find a place to learn, grow, and achieve…a place to call your professional home. We provide the opportunity for a career with purpose in an environment that values achievement and supports a balance between personal and professional lives.

We invite you to join us at Covance and to work with us in bringing hope to millions of patients around the world. We believe this decision may be the most rewarding career move you will ever make.

We currently have an opening at our Greenfield, Indiana facility for a Research Associate, Neuroscience. As a Research Associate, you will organize and analyze the results of in vivo behavioral studies conducted in rodents and large animals.

The minimum education, experience and qualifications include:

Bachelor or Master of Science degree in Neuroscience-related field
3–6 years of behavioral testing experience
Prior experience related to behavioral science/neuroscience is preferred
Rodent and/or primate handling and dosing experience
Proficiency in statistical analysis, graphics software and/or data reduction software desired
Proficiency in Microsoft Office applications (particularly Word and Excel)
Ability to interact with clients and present information to both clients and team members
Strong communication skills and the ability to interact with technicians, research associates and senior scientists across Covance

At Covance, we help make the miracles of medicine a reality. We offer opportunities to work on diverse, challenging projects with bright, interesting colleagues while building a flexible, and rewarding career. Covance’s ongoing success offers team members unsurpassed growth and career development opportunities. To find out detailed information about this opportunity, please visit our website at: www.careers.covance.com and search for requisition ID number 31985 or 31987.

Diversity within Covance is alive and universal. EOE

Posted November 23, 2011

Company Name: Pfizer
Location: Connecticut, Groton
Job Title: Ion Channel Pharmacology Scientist (R2-Sr. Associate Scientist/R3-Scientist)

Job Focus

Global Safety Pharmacology (GSP) is seeking a talented individual to conduct ion channel pharmacology studies in support of World Wide Research and Development. The successful candidate will join a multidisciplinary team engaged in conventional patch clamp as well as high throughput ion channel screening of test articles for assessment of liability. The candidate will conduct and interpret in vitroelectrophysiological safety studies, and interact with members of the laboratory, colleagues within GSP and members of research groups to communicate results and provide guidance with respect to safety. Responsibilities will include isolation of cardiac myocytes from various animal species, cell line maintenance and culture, compound screening in established electrophysiological assays, and assistance in developing, optimizing, trouble shooting and validating new assays on automated and manual electrophysiology platforms. Additionally the incumbent will be responsible in part for liquid handling of compounds, database management, electronic compound submission and tracking.

Responsibilities/Qualifications

Minimum:
This position requires a candidate with a B.S. degree and 2+ years of relevant experience in the pharmaceutical setting with experience with a variety of electrophysiological techniques.

Desirable:
The role requires detailed knowledge and experience of ion channel electrophysiology, particularly with recombinant mammalian cell-based expression systems, and isolated cardiac myocytes. The successful candidate will have broad knowledge of ion channels together with experience in manual and automated patch clamp electrophysiology. A positive attitude and the willingness to organize, execute, and manage multiple concurrent projects and timelines is essential.

Work Experience/Skills:
Demonstrated experience with a variety of electrophysiological techniques, including manual and automated patch clamp electrophysiology and knowledge of the QPatch automated clamp system is a must. Experience with cardiac cell isolation from various animal species as well as maintenance and culture of recombinant mammalian cell lines and liquid handling is highly desirable. Contribution to the overall strategy of the ion channel group by maintaining an up to date awareness of technical and drug discovery related literature is expected. Experience with electronic equipment, computer data collection, analysis and management programs related to electrophysiology is required. Ability to solve problems and trouble shoot instrumentation in a team setting is essential. Excellent verbal and written communication skills and ability to interact with scientists throughout the organization is also required. The successful applicant must be selfmotivated and have a strong desire to succeed in a team setting, and the ability to meet goals working in a group of peers.

To be considered please apply on-line at www.pfizercareers.com and search for job ID 958056.

Posted November 21, 2011

Company Name: Battelle
Location: Columbus Ohio
Job Title: Study Director

Fast Forward to Your Growth

As part of Battelle’s Health and Life Sciences Global Business, you will touch every aspect of human health. We deliver far reaching solutions to some of the world’s most pressing health challenges – from developing medical products that change individual lives to pharmaceuticals that address potentially devastating health conditions on a global scale. Battelle supports your career by offering you the opportunity and resources to solve the most critical health problems, break through technology developments, mentorship opportunities, upward mobility, and company ethics and reputation. Are you ready to Fast Forward To Your Growth?

Our Health and Life Sciences Division is currently seeking a Study Director. This position located in Columbus Ohio.

Position Responsibilities:

Perform and direct Safety Pharmacology studies in compliance with GLP regulations under the general direction of the Safety Pharmacology Manager or designate. Supervise junior staff in the conduct of studies. Develop SOPs, Forms, Methods, Procedures, Protocols, Reports and Proposals. Review, analyze and interpret data generated using animal studies to write reports of cardiovascular, pulmonary and other related studies. Present seminars and presentations to clients and prepare abstracts, posters and manuscripts for scientific meetings and publications. Interact with clients regarding work performed.

The following requirements must be met to be considered for this position:

Requires a Master's degree in Physiology or related field and a minimum of 3 years experience in preclinical regulatory safety pharmacology or related field OR Bachelor's degree with a minimum of 7 years experience in preclinical regulatory safety pharmacology or related field.
Must have at least 3 years experience study directing preclinical regulatory studies or equivalent.
Must be capable of interpreting and understanding the various specifications of individual study protocols and program designs and organizing logistics between study management and technical staff to ensure the precise conduct of the study protocol.
Excellent English language, composition and grammar communication skills.
Demonstrated ability to multi-task, prioritize, schedule and organize work; perform under tight deadlines and adapt to changing priorities.
Must have working knowledge of Good Laboratory Practices regulations.
Word processing and computer skills; familiarity with Microsoft Office software packages (MS Word, Excel, Outlook, etc.); experience with Adobe Acrobat software is helpful.
Ability to work in a team setting.

The following requirements are desired:

Three years experience in safety pharmacology/physiology studies.
Hands on experience with various animal and ex-vivo models
Demonstrated ability to innovate research models.
Working knowledge of both GLP and OECD regulatory requirements.
Ability to communicate and develop business relationships with clientele.
Working knowledge of computer acquisitions systems (EMKA, DSI, BUXCO, etc.).
Working knowledge of EMKA ECGAuto post processing software.
Experience with quantitative and qualitative assessment of electrocardiograms.

Benefits

Battelle’s competitive benefits program includes comprehensive medical and dental care, matching 401K, employee pension, tuition reimbursement, work/life balance, paid time off, flexible spending accounts, disability coverage, and other benefits that help provide financial protection for you and your family.

Battelle is an Affirmative Action/Equal Opportunity Employer and supports diversity in the workplace. Applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, disability, veteran status, marital status, or sexual orientation. For more information about our other openings, please visit www.battelle.org/careers.

Posted November 8, 2011

Company Name: Pfizer
Location: United States-Connecticut-Groton
Job Title: Senior Lab Scientist (CV Safety Pharmacology) (Sr. Scientist / Principal Scientist)

Job Focus
The Global Safety Pharmacology Center of Emphasis (GSP) in Drug Safety Research and Development (DSRD) is a multi-site resource focused on the proactive management of safety pharmacology issues and their translation to human. The Center of Emphasis supports all therapeutic areas from idea to loss of exclusivity including experimental approaches to aid target and compound selection, regulatory pre-FIH safety studies and post-FIH investigative studies to address clinical findings and manage risk.

The role is for an experienced lab scientist with subject matter expertise in the cardiovascular field, and will require the design, conduct, interpretation and communication of in-vivo studies to support the safety pharmacology assessment of projects across the portfolio.

The primary focus of this role will be to provide expertise in pharmacological and pathophysiological modulation of cardiac and vascular structure and function.

The role will require the development of in vivo models to support the preclinical safety pharmacology assessment of novel compounds, including:

Echocardiography in standard non-rodent toxicology species (M-mode, 2D, Doppler, etc.)
Cardiac pressure/volume loops,
Potential assessment of regional blood flow and vessel diameter

The scientist will demonstrate an ability to integrate these functional assessments into a broader interpretation of systemic CV risk, providing a mechanistic understanding of the observed profile and their likely translation to human.

The individual will be expected to contribute to the coaching and mentoring of other junior colleagues within the discipline and the day to day management of laboratory work.

This scientist will possess good technical problem solving skills, applied to improving and implementing new methods and technologies.

This scientist will be independent, proactive and self directed with limited technical supervision. They will have a good understanding of cardiovascular pharmacology, and use the scientific literature to design experiments/studies and understand the results within the CV area.

Responsibilities
Working in the CV discipline to support target and compound safety through the design, conduct, interpretation and communication of in vivo safety studies. This will involve the integration of their experimental data with other safety pharmacology and project data to develop a mechanistic understanding for a CV effect and its likely translation to human.

Using the scientific literature and available in house data to design and interpret studies.

The individual will be expected to contribute to the coaching and mentoring of other colleagues within the discipline and the day to day management of laboratory work.

Leads/drives the development of new methodologies/assays/models

Qualifications
A BSc, with several years experience working in the area of cardiovascular, preferably with an MSc or a PhD in pharmacology, physiology or a related biological discipline.

Required Experience: Design, conduct and interpretation of in-vivo cardiovascular studies, especially echocardiography (preferably non-rodent), cardiac pressure/volume loops, and potentially regional blood flow/vessel diameter in rodent or non-rodents.

To be considered please apply online at www.pfizercareers.com and search for Job ID 957738.

Posted October 21, 2011

Company Name: Vertex Pharmaceuticals
Location: Cambridge, MA
Job Title: Associate Director, Safety Pharmacology, Toxicology

Description:

The toxicology department is responsible for the design and conduct of preclinical safety studies for comprehensive assessment of Vertex therapies and has a pivotal role in both the Discovery and Development organizations. Members have significant roles in the drug development process beginning in the early Drug Discovery process and continuing through the entire drug development value chain through registration and marketing.

The Associate Director, Safety Pharmacology, will lead the strategy of Safety Pharmacology from discovery research through development and marketing of the Company's therapeutics. The department brings together a variety of backgrounds including electrophysiology and pharmacology.

Key Responsibilities:

Build and enhance the capabilities within the Safety Pharmacology group
Manage in vitro and in vivo safety pharmacology laboratories and design, implement, and interpret appropriate safety pharmacology studies for the development of novel new drug candidates
Advise, strategically plan, and manage safety pharmacology programs for the research and development phases of new drug candidates
Coordinate outsourcing activities of safety pharmacology studies as needed
Contribute to the overall risk assessment process and prepare contributions to national and international regulatory documents as needed
Design and implement a strategy to establish the Cambridge site as the Safety Pharmacology Global Center of Expertise
Communicate unambiguous critical and significant project information to various bodies including the project teams, the Head of Toxicology and other Vertex leadership as required
Mentor colleagues and design well defined development plans for members of the Safety Pharmacology group
Build strong scientific collaborations with external groups within both the academic and industrial sectors
Interact effectively and build collegial working relationships with the discovery groups at all Vertex sites external to Cambridge
Assume a leadership Safety Pharmacology role to advise, mentor, and serve as an expert resource for the entire Vertex community

Qualifications:

PhD in Safety Pharmacology, Toxicology, and Pharmacology or other scientific fieldS
8+ year’s experience in the Pharmaceutical Industry with proven abilities in leading a team of scientists within the Safety Pharmacology arena
Recognized authority in the field of Safety Pharmacology/Toxicology with credibility in Safety Pharmacology
Proven supervisory experience as well as the ability to attract, develop, and manage top-tier talent
Proven ability to creatively seek resolutions to scientific issues that arise during development of new therapeutics

Preferred Qualifications:

Excellent cross-functional team leadership and participation skills.
Ability to lead and motivate others, both within direct supervisory and matrixed environments
Results and goals oriented
Superb verbal and written skills with the ability to present clear and concise presentations to teams and senior management and the ability to present credible and unambiguous opinions that influence global project decisions
Strong problem solver who is highly organized with the ability to thrive and to lead in a highly matrixed environment, with rapidly changing priorities
Strong interpersonal skills with an ability to develop strong, long term relationships and the ability to influence others
The ability to work in a fast-paced environment in an organization that strives for success and maintains high quality standards

Apply:
To apply for this position, use the link below:
http://appclix.postmasterlx.com/track.html?pid=ff80808132ca9013013303877dd006dd&source=safetypharmacologysociety

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Posted September 16, 2011

Company Name: Novartis
Location: Basel (Switzerland) or East Hanover (New Jersey USA)
Novartis will support international family relocation
Job Title: Global Head, Safety Pharmacology (Director/Executive Director)

Lead Novartis to best-in-class Safety Pharmacology performance

Business area
Preclinical Safety, Translational Sciences, Novartis Institutes for BioMedical Research

Principal Scientific Leader for Safety Pharmacology and its application to drug discovery and development, translating preclinical data into the clinical situation

Represent and champion Safety Pharmacology within Preclinical Safety, Translational Medicine, research Disease Areas (particularly Cardiovascular, Neuroscience, Respiratory), other Key Opinion Leaders, and Regulatory Authorities

You will lead Safety Pharmacology and influence our community scientifically: your project and program leadership will deliver high value risk management and safety profiling. That’s an exciting proposition: your ideas and work will have significant impact on compounds moving safely forwards into Development.

Lead the global Safety Pharmacology function in Preclinical Safety at Novartis, including responsibility for quality, timeliness and availability of the appropriate resources for internal decision making regarding risk and for satisfaction of regulatory expectations.
Maintain and develop overall scientific and regulatory expertise in safety pharmacology. Take a leadership role within Preclinical Safety regarding all aspects of Safety Pharmacology
Set short-term and long-term strategies for the Safety Pharmacology function in collaboration with the PCS Leadership Team
Ensure adequacy of capabilities and resources to operate the function in a comprehensive manner consistent with program/project needs and regulatory expectations
Primary Safety Pharmacology contact and interface for PCS Therapeutic Area Heads and PCS Line Unit heads
Develop and maintain a network of external scientific support providers and consultants for the Safety Pharmacology function
Work with the Global Head of Genetic Safety to select and support qualified scientists from the group to be the Safety Pharmacology member of PCS Target Teams and TA Strategy Teams
Develop talent for TA portfolio needs and priorities
Manage and supervise scientific and technical staff

Your experience

Safety Pharmacology Doctorate level degree—PhD, MD—in a biological or medical science with strong evidence of recent publications in peer-reviewed scientific journals
Strong experience in a drug discovery/drug development organization or closely related academic field with relevant leadership in one or more Safety Pharmacology disciplines
Evidence of successful integration of relevant findings across multiple study types (e.g., in vitro, in vivo, mechanistic) and between clinical and nonclinical data
Excellent understanding of current literature, concepts and controversies in Safety Pharmacology as they relate to human risk estimation and translation into successful preclinical safety strategies
Contributions to successful NDAs/MAAs/PLAs (Safety Pharmacology and relevant preclinical and clinical interpretations)
Demonstrated proficiency in database applications and use in decision making
Extensive experience with external vendors for scientific and regulatory work
Successful Line and Team Management, coaching and people development

Apply www.novartis.com/careers/job-search using job ID 87145.
Contact tim.symes@novartis.com with any questions.

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Posted August 25, 2011

Company Name: The Wyss Institute for Biologically Inspired Engineering at Harvard University
Location: Boston, MA
Job Title: Postdoctoral Fellow

The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for a postdoctoral fellow position in the Biomimetic Microsystems platform. The mission of the Wyss Institute is to discover the engineering principles that Nature uses to build living things; to pursue the high-risk research that is fundamental to advance this effort; and to harness these insights to create biologically-inspired materials and devices to advance human health and improve the environment—thereby revolutionizing clinical medicine and creating a more sustainable world.

We seek outstanding postdoctoral applicants with expertise in respiratory cell biology and physiology and/or surface barrier (mucosal) inflammation to join an interdisciplinary team of biologists and engineers for the development of novel in vitro “organ-on-chip” microsystems technologies to study and model pulmonary disorders (Huh D et al. Science 2010). Applicants are expected to hold a PhD or MD and have a proven record of high quality publications in respiratory biology and/or surface barrier inflammation. Strong interest in contributing to multidisciplinary teams (engineers, biologists/physiologists, clinicians) is critical for this position. Expertise in in vitro culture of respiratory cell lines and primary human cells, as well as knowledge of basic molecular biology concepts and techniques is a must. The ideal candidate would bring expertise in respiratory cell biology, physiology, and pathophysiology, with an interest in applying this expertise in combination with modern bioengineering methods such as microfabrication and microfluidics. This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered human “organ-on-chip” models and exploring their use for drug discovery applications.

Applications, assembled as a single PDF file, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation).

Applications should be sent to faculty_postdocs@wyss.harvard.edu.

For additional information please visit our webpage:
http://wyss.harvard.edu/

Harvard University is an Equal Opportunity/Affirmative Action employer and applications from women and minority candidates are strongly encouraged.

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Posted July 6, 2011

Company Name: Covance
Location: Madison, WI
Job Title: Safety Pharm Study Director

Imagine being involved in cutting edge projects that change the course of our industry on a daily basis. At Covance, one of the world’s largest and most comprehensive drug development service companies, you will have an opportunity to build an exciting career while you make a direct impact on the lives of millions.

We currently have an opening for a Study Director in our Safety Pharmacology department. This position serves as a Study Director on cardiovascular, central nervous system and/or respiratory safety pharmacology studies in rodents and non-rodents, as described in ICH and GLP regulations/guidelines. The director has overall responsibility for the technical conduct of a study as well as for the interpretation, analysis, documentation and reporting of results.

Qualifications Include:

PhD, DVM, or an equivalent degree
Three to five years of experience

At Covance, we help make the miracles of medicine a reality. We offer opportunities to work on diverse, challenging projects with bright, interesting colleagues while building a flexible and rewarding career. Covance’s ongoing success offers team members unsurpassed growth and career development opportunities. To find out detailed information about this opportunity, please visit our Web site at: www.covancecareers.com and search for Req. ID 28221.

Diversity within Covance is alive and universal. EOE

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Posted May 23, 2011

Company Name: Vertex Pharmaceuticals
Location: Cambridge, MA
Job Title: Safety Medical Director

Description:

The Medical Director of Global Patient Safety will have the dual responsibility of providing safety oversight for Vertex’s pipeline of early development products, from first-in-human studies through proof-of-concept (Phase I&II), as well as leading all aspects of the Medical Operations group within the department. The Director of Global Patient Safety will oversee responsibility for the clinical assessment of AE and SAE case reports, as well as the production and review of aggregate, ad hoc and periodic reports. This individual will also be responsible for the development and establishment of standards and practices for medical assessment and reporting, as well as implementation of signal detection and risk management practices at the outset of clinical programs.

Key Responsibilities:

Oversee development and implementation of standard processes and procedures for all medical aspects of adverse event report handling, assuring compliance with global Pharmacovigilence regulations including U.S. FDA/ICH regulations governing safety reporting for individual as well as aggregate reports
Oversee day to day conduct of all Medical Review activities including responsible staff, as applicable
Serve as Global Safety Officer for early development drug candidates and programs
Provide safety content to key study-related documents for assigned products including IB, ICF, Protocols, Statistical Plans
Serve as Medical Safety expert on the Dictionary Advisory Committee
Participate in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports
Implement and lead cross-function teams responsible for the establishment of the early risk-benefit profile for assigned products
Provide matrix support to Franchise Safety Therapeutic-area Leads as needed
Contribute to preparation and review of periodic reports (IND, Annual Safety, PSUR, PADER)
Serve as department Medical lead in collaborations with key external stakeholders, including: Partners, CROs and Consultants
Effectively communicate objectives of Clinical Operations team to the group and department, as well as appropriately disseminate department information to cross-functional teams
Participate in departmental development activities including SOP and Work Instructions development, Audits

Preferred Qualifications:

Excellent verbal and written communication skills
Self-starter with proven ability to thrive in a fast-paced environment handling multiple simultaneous high priority tasks
Solid knowledge of general medicine evidenced by medical training and medical practice experience

Qualitifications:

M.D. required with a minimum of 2 to 3 years of direct Pharmacovigilance experience

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company’s strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex’s product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer, and pain.

VERTEX is an Equal Employment Opportunity/Affirmative Action employer. All employment decisions are made without regard to race, sex, national origin, color, religion, age, disability, veteran status or any other status protected by federal, state or local law

Apply:

Visit the Web site to apply on-line.

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